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How long can prednisone be in your system?

1 doctor weighed in
Dr. Thomas Namey
Internal Medicine - Rheumatology

In brief: Depends!

Prednisone has a pre conversion half life off one hour. Prednisone is a converted into prednisolone, which also has "steroid" effects! its plasma half life as Prednisolone is 2-3 hours.
So the total effect a duration of 18-36 hours. But once its out of your system it takes a while for your system to re-regulate itself as well.

In brief: Depends!

Prednisone has a pre conversion half life off one hour. Prednisone is a converted into prednisolone, which also has "steroid" effects! its plasma half life as Prednisolone is 2-3 hours.
So the total effect a duration of 18-36 hours. But once its out of your system it takes a while for your system to re-regulate itself as well.
Dr. Thomas Namey
Dr. Thomas Namey
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