If neither parent shows signs of having sickle cell anemia, does this guarantee that their children will not get it?

No. There is a 25% chance of two people with sickle cell trait to have a child with sickle cell disease.
No. Sickle cell disease usually occurs in infants born to parents who are totally asymptomatic. The carrier state for ss disease affects 8% of the afro-american population in the us.These carriers have no outward signs but will have a positive screening test for trait.Every conception between two carrier(trait) parents has a 25% risk of having sickle cell and 50% of becoming a carrier.

Related Questions

Is it possible for children whose parents have sickle cell anemia to not get it? What are the odds?

Depends on situation. If both really have sickle cell anemia, the kids they have together will all have sickle cell. If you mean they both carry a trait, they can have normal, trait or sickle cell kids. Read more...

Do one or both parents have to have sickle cell anemia in order for this trait to pass on to their children?

No. The parents could both be carriers of the sickle cell mutation on one of their two beta globin genes. Their other gene could be normal. This condition is called sickle cell trait. These people are usually asymptomatic with normal red cell indices. The child could have two copies of the mutant beta globin gene, one from each parent. Their is a 25% chance of this. For more details, consult your dr. Read more...
Enter an answer. Only one parent with sickle cell disease (2 genes positive for hemoglobin s) is needed to pass the sickle cell trait (one gene) on to their children. Patients with only one gene are considered to have sickle trait only, and do not have the severe form, sickle cell disease, where both genes carry sickle cell mutation. Read more...

What are the possible parental screening tests available for sickle cell anemia?

Hb electrophoresis. Both parents of a child with sickle cell anemia in most instances, but not always should have sickle cell trait. This could be confirmed by a test, 'hemoglobin (hb) electrophoresis'. There is a simple test called 'sickledex' test. But this test does not tell you if you have sickle cell disease or trait. If both parents have trait, each offspring has 25% chance of having a child with disease. Read more...

What are symptoms of sickle cell anemia in school children?

Not much. Sickle cell disease is seldom subtle. Patients have intermittent periods of intense pain, often in bone, they have all manifestations of profound anemia, including diminished exercise tolerance, shortness of air, generalized fatigue, etc. This is a very bad disease with few subtle manifestations. Read more...