Is it safe to take Abilify (aripiprazole) with Benadryl and xanax? It uses enzymes 2d6 & 3a4. Benadryl uses 2d6 and Xanax uses 3a4. Prescribed, of course. Curious..

Abilify (aripiprazole) . It is safe to combine those medications. Regardless of their metabolic pathways, most likely there will be no important interactions in between them, and you will not notice any side effect related to their combination. Abilify (aripiprazole) may cause restlessness and Benadryl and xanax reduce restlessness, therefore they will reduce side effects.