What is the best treatment for rickettsial infection?

Rickettsial Rx. Doxycycline is the drug of choice; it is preferred over other tetracyclines for treatment of rickettsial infections. Chloramphenicol may be used as an alternative but it has potential bone marrow toxicity. Recent data from europe suggest that fluoroquinolones, such as Ciprofloxacin and ofloxacin, may be effective in the treatment of certain rickettsial infections.