Is it likely to develop an allergy to benadryl (diphenhydramine)? I've seen 1 or 2 tiny hives and slight flushing, feel nervous, after taking it. I take dye-free.

Benadryl (diphenhydramine) Allergic reactions to Benadryl (diphenhydramine) are unusual but they do occur. Benadryl (diphenhydramine) does have side effects such as sedation or agitation. Hives and flushing can be seen with allergic reactions. A visit to the doctor may help sort this out.

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