4 doctors weighed in:

Can valerian cause depression?

4 doctors weighed in
Dr. Leslie Howell
Psychiatry
3 doctors agree

In brief: Possible

Valerian affects the GABA receptor system in the brain which can help with anxiety and insomnia.
Large doses or long term use can cause a feeling of mental dullness or mild depression. Xanax (alprazolam) has the same effect on the body. Since they are both central nervous system depressants, they should not be used together.

In brief: Possible

Valerian affects the GABA receptor system in the brain which can help with anxiety and insomnia.
Large doses or long term use can cause a feeling of mental dullness or mild depression. Xanax (alprazolam) has the same effect on the body. Since they are both central nervous system depressants, they should not be used together.
Dr. Leslie Howell
Dr. Leslie Howell
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