Scleroderma. Scleroderma is a connective tissue disease (ctd). The best treatment is based on treating the affected system or organ cause. For instance: ctd may be manifested as pulmonary hypertesnion, lupus, esophageal narrowing, kidney disease. Is so hard to explain on the internet, but better to understand and explain if i;m able to examine you and do the proper work up and referrals.
Truly none. As scleroderma has no cure, it is difficult to talk about the best treatment. What is treated are the manifestations of scleroderma. For vascular issues such as raynaud's phenomenon, there are topical and oral medications. For kidney disease or pulmonary hypertension, it is essential to initiate treatment as early as possible to prevent organ failure or death. Treatment depends on the organ system.
Best Rx? Most rheumatologist use calcium channel blockers for raynaud's. D-penicillamine is felt to work, but there are no controllled trials. Methotrexate and tetracycline (minocycline or doxycycline) or though by many colleagues to help. However, long term controlled trials are lacking. We can treat BP problems, pulmonary hypertension much better, with never drugs.