7 doctors weighed in:

What is the difference between the anachoice screen and the ANA screen, ifa? The first one came back positve, but the second came back negative.

7 doctors weighed in
Dr. John Goldman
Internal Medicine - Rheumatology
3 doctors agree

In brief: IFA better

For a screen the ifa is much better. It is the gold standard.
The ANA choice is not a screening test and should not be offered as a screening test. Your question is somewhat counter intuitive. The ifa is a better test and if choice is positive - it can be subseted into 12 antigens and the lab can tell you. I would follow your test results with ANA subsets per your rheumatologist.

In brief: IFA better

For a screen the ifa is much better. It is the gold standard.
The ANA choice is not a screening test and should not be offered as a screening test. Your question is somewhat counter intuitive. The ifa is a better test and if choice is positive - it can be subseted into 12 antigens and the lab can tell you. I would follow your test results with ANA subsets per your rheumatologist.
Dr. John Goldman
Dr. John Goldman
Thank
Dr. Gurmukh Singh
Pathology
2 doctors agree

In brief: Different methods

Different methods of doing a lab test will some times give different results.
If one of the tests is negative, it is unlikely that you are at high risk of having a disease associated with anti-nuclear antibodies. It would be prudent to repeat the test in about a year, especially if you continue to have symptoms that prompted the test in the first place.

In brief: Different methods

Different methods of doing a lab test will some times give different results.
If one of the tests is negative, it is unlikely that you are at high risk of having a disease associated with anti-nuclear antibodies. It would be prudent to repeat the test in about a year, especially if you continue to have symptoms that prompted the test in the first place.
Dr. Gurmukh Singh
Dr. Gurmukh Singh
Thank
1 comment
Dr. John Goldman
In part it depends on the patient. There are people with CTD who have had a negative result by ANA choice but have active Illness. This has been documented. The IFA is the correct screen - not the ANA choice. After that an evaluation will clarify. Treat the patient and not the lab tests, but use a decent lab test.
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