How can I treat primary sclerosing cholangitis?

Difficult problem. Psc: autoimmune swelling/scarring of bile ducts within and outside the liver; often associated with infl. Bowel (usually ulc colitis). Increased risk for biliary ca. Med rx for itch, biochem abnormalities, e.g. Urso (bear bile), antihistamines, antibiotics for infections, vitamin supllements for deficiencies. Ercp procedure may open some strictures (narrowing). Ultimately, may need liver transpla.
Ursodiol. Standard treatment includes ursodiol, a bile acid naturally produced by the liver, which has been shown to lower elevated liver enzyme numbers in people with psc, but has not improved liver- or overall survival. Invasive approaches include ERCP and stunting are needed to open major blockage. Liver transplant is the only proven long term treatment.

Related Questions

Is primary sclerosing cholangitis rare?

Yes. The goal of managing acute attacks is antibiotics and IV fluids. In about 15%, emergency decompression or surgery is needed. Prevention of future attacks of cholangitis is based on removing biliary stones and debris, dilation or resection of strictures, and establishing optimal biliary drainage. Also important to rule out the clonorchis parasite. Your GI doctor can discuss newest treatments.

Primary sclerosing cholangitis, what is this like??

Bile duct obstructio. Idiopathic (probably autoimmune) progressive scarring and narrowing of the bile ducts. May need surgical intervention or transplant This reference may help: http://www. Mayoclinic. Org/diseases-conditions/primary-sclerosing-cholangitis/basics/definition/CON-20029446.

Could you explain what is primary sclerosing cholangitis?

Bile duct scarring. Primary sclerosing cholangitis (psc) is an inflammatory disease of the bile ducts that causes scarring and subsequent obstruction of bile ducts inside and/or outside the liver. This blocks the flow of bile to the gut, which can ultimately lead to cirrhosis of the liver. The underlying cause of psc is not entirely known, but believed to be an auto-immune disorder with a strong association with uc.

Primary sclerosing cholangitis - what is the inherited risk?

Very low. PSC is most commonly seen in patients with ulcerative colitis. Patients with PSC have 60-72% association with ulcerative colitis; low genetic and immunologic factors are attributed to PSC.

Does primary sclerosing cholangitis usually cause many symptoms?

It can. Primary sclerosing cholangitis (= psc, inflammation of bile ducts) can give symptoms such as itching, pain in the right upper abdomen, fevers, chills, night sweats, and jaundice (yellow skin, yellow whites of the eyes). Most people with this illness have ulcerative colitis, which has symptoms of its own (eg. Bloody diarrhea, abdominal pain). Many with psc eventually need liver transplant.

What is the definition or description of: primary sclerosing cholangitis?

PSC. Primary sclerosing cholangitis (psc) is a chronic liver disease caused by progressive inflammation and scarring of the bile ducts of the liver. The inflammation impedes the flow of bile to the gut, which can ultimately lead to liver cirrhosis, liver failure and liver cancer. The underlying cause of the inflammation is believed to be autoimmunity.
PSC. Primary sclerosing cholangitis is a disease of the bile ducts of the liver. Cholangitis refers to inflammation of the bile ducts, whereas sclerosing refers to the scarring of the bile ducts that results from chronic inflammation. Primary sclerosing cholangitis is a progressive disease that leads to liver damage and, eventually, liver failure.