What is hemolytic-uremic syndrome (hus)?

Kidney disease. Caused by break down of red blood cells (hemolysis) that is caused by minute clots ( microthrombi )in capillaries in kidneys and other organs including brain. The resultant blockage of kidney and brain circulations cause kidney failure and seizure respectively. Not all cases have obviously diagnosable reason but an infection with certain kind of e.Coli bacteria can cause it and that can be fatal.
Toxic Kidney Injury. Hus is a disorder that usually occurs when an infection in the GI tract (such as e.Coli o157:h7) produces toxic substances that damage blood vessel lining, cause hemolytic anemia and lead to kidney failure. It is a serious infectious complication that can actually be made worse with antibiotics.

Related Questions

What's a hemolytic-uremic syndrome?

HUS is... An illness with hemolysis (breaking apart of red blood cells) and uremia (kidney failure) and sometimes with central nervous system symptoms. It is mostly a complication of infection with enterohemorrhagic e. Coli (usually o157) that begins with diarrhea that becomes bloody, significant abdominal pain and little fever. The risk of hus is really increased by antibiotic use during the diarrhea. Read more...
HUS... Hemolytic-uremic syndrome (hus) is a disorder that usually occurs when an infection in the digestive system produces toxic substances that destroy red blood cells, causing kidney injury. Hus often begins with vomiting and diarrhea, which may be bloody. Within a week, the person may become weak and irritable. Persons with this condition may urinate less than normal. Urine output may almost stop. Read more...

What things cause hemolytic-uremic syndrome?

Certain E. coli. Enterohemorrhagic e. Coli, usually type o157, is the most common cause of hus which begins about one week into the bloody diarrhea illness. The risk of hus is prominently increased if antibiotics are used during the diarrheal illness. Read more...

What are the tests for hemolytic uremic syndrome?

See below. Hemolytic uremic syndrome (hus) usually follows an acute episode of diarrheal illness caused by enterohemorrhagic e. Coli. Acute renal failure and increased red cell destruction are the hallmarks of hus. Rising serum creatinine level and reticulocyte counts would be expected. Read more...

What are the symptoms of hemolytic uremic syndrome?

See below. This is a rare but serious disorder which has many causes.Hemolysis means destruction of red blood cells and uremia is kidney failure.Most well known cause is after eating contaminated food /meat with pathogenic e colii bacteria.Diaarhoe, jaundice, renal failure occur and bllod test are available to detect the liver and kidney failure and also the specific bacterial antigen. Read more...
Variable. Hemolytic uremic syndrome involves damage to tiny blood vessels that breaks down red blood cells and uses up platelets leading to weakness, pale color, and bleeding. Damage often affects kidneys, leading to abnormal urine or even kidney failure. Other organs may also get damaged, including the pancreas, brain, and liver. Symptoms depend on which organs get damaged as well as the level of anemia. Read more...

What are the issues with hemolytic uremic syndrome?

Concern about kidney. Hemolytic uremic syndrome (hus) is a condition that results from the abnormal premature destruction of red blood cells. Blood cells start to clog the filtering system in the kidneys, which may eventually cause the life-threatening kidney failure seen in hus. Most cases of hus develop in children after colon infection due to e.Coli. Adults can also get hus but often the reason is not due to e.Coli. Read more...

How common is death from hemolytic-uremic syndrome?

Depends on type. Children with enterotoxic hus die 5% or less. With atypical hus the death rate is higher with chronic recurrent episodes. Read more...
HUS mortality. It is estimated that ~5% die from hemolytic-uremic syndrome. Adults usually fare worse than children (and the underlying etiology of the disease is different). Read more...

What are different ways to treat hemolytic uremic syndrome?

HUS has diff types. Most of the cases that relate to e.Coli or sigella food poisoning, hemorrhagic diarrhea if severe, recover spontaneously and not even see the doctor. The ones who have to see a doc are the severe cases d/ t e.Coli or unknown cause not relating to diarrhea. These mostly need plasma exchange. A new report suggests that the diarrhea mechanism may be blocked with oral manganese. It may not help hus. Read more...