2 doctors weighed in:

Can there be a set karyotype for acute lymphocytic leukemia?

2 doctors weighed in
Dr. Michael Engel
Pediatrics - Hematology & Oncology

In brief: No.

Gross structural changes in chromosome number and structure can be identified by karyotype.
There are many such changes associated with all development, yet many all patients have normal karyotypes. This doesn't mean mutations are absent. Modern techniques let us see changes across the genome at single nucleotide resolution. The critical role of epigenetic change is now also firmly established.

In brief: No.

Gross structural changes in chromosome number and structure can be identified by karyotype.
There are many such changes associated with all development, yet many all patients have normal karyotypes. This doesn't mean mutations are absent. Modern techniques let us see changes across the genome at single nucleotide resolution. The critical role of epigenetic change is now also firmly established.
Thank
Dr. Michael Dugan
Internal Medicine - Hematology

In brief: In short no

The karyotype is important, and certain changes are higher risk such as t (4, 11) and t (9;22).

In brief: In short no

The karyotype is important, and certain changes are higher risk such as t (4, 11) and t (9;22).
Thank