Are there some genetic reasons I got an e. Coli infection in the urine more than once?

No. Ecoli utis are the most common infection in women. It usually relates to wiping technique or tight fitting clothe oth something that irritate the urethral opening that make it avorable for bacterial entrance into the urinary tract this includes post intercourse UTI .. It considered average if female get ecoli UTI 2x annually. Buut it is imprtant to identify why and prevent as much as you can.