Do you rule out aps if anticardiolipin antibody and beta 2 glycoprotein (both IgG and igm) are often elevated but in borderline and weakly positive range?
See below. There are certain criteria that must be met in order for one to have aps. One of which is that one must have some type of thrombotic event. Antibodies alone do not make the diagnosis. Without knowing full details regarding your case, it is difficult to say whether you do or not.
No. The diagnosis depends on a combination of clinical andlaboratory findings. Data is supportive but we need more information. Other data that would be important is the result of the lupus anticoagulant evaluation. The data regarding your clinical findings are very relevant here.
No, but... Testing for antiphospholipid antibodies is useful but not 100% accurate. In a recent study, each antibody was positive in about 50-80% of aps patients, and the likelihood of aps was higher with more positive antibodies. However, a few patients will not have any of the antibodies we test for and must be diagnosed based on clinical features such as blood clots and recurrent miscarriages.