7 doctors weighed in:

How does hypercalcaemia cause pancreatitis?

7 doctors weighed in
Dr. Paxton Daniel
Radiology
4 doctors agree

In brief: Conjecture

Nobody really knows but some suggest that hypercalcemia induces pancreatic injury via a secretory block, accumulation of secretory proteins, and possibly activation of enzymes that begin to digest the pancreas.

In brief: Conjecture

Nobody really knows but some suggest that hypercalcemia induces pancreatic injury via a secretory block, accumulation of secretory proteins, and possibly activation of enzymes that begin to digest the pancreas.
Dr. Paxton Daniel
Dr. Paxton Daniel
Thank
1 comment
Dr. Geoffrey Rutledge
THese two studies confirm Dr. Daniel's answer, based on what high calcium levels to to the rat pancreas: http://www.ncbi.nlm.nih.gov/pubmed/7817987 http://www.ncbi.nlm.nih.gov/pubmed/7540999
Dr. Jack Rubin
Internal Medicine - Nephrology & Dialysis
1 doctor agrees

In brief: Pancreatitis causes

Hypercalcemia (h) is not a known cause of acute pancreatitis (p).
P is most commonly caused by alcoholism or gall stones. Other causes can be due to drugs and high triglyceride levels. H, however, is not recognized as a cause of p.

In brief: Pancreatitis causes

Hypercalcemia (h) is not a known cause of acute pancreatitis (p).
P is most commonly caused by alcoholism or gall stones. Other causes can be due to drugs and high triglyceride levels. H, however, is not recognized as a cause of p.
Dr. Jack Rubin
Dr. Jack Rubin
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Dr. Philip Kern
Internal Medicine - Endocrinology

In brief: Not really known

Presumably, high blood ca makes the pancreatic cells more susceptible to self-degradation.
Extreme hypercalcemia (eg. Cancer) is more likely to do this. Pancreatitis from mild hypercalcemia (benign conditions such as primary hyperparathyroidism) is rare, but possible.

In brief: Not really known

Presumably, high blood ca makes the pancreatic cells more susceptible to self-degradation.
Extreme hypercalcemia (eg. Cancer) is more likely to do this. Pancreatitis from mild hypercalcemia (benign conditions such as primary hyperparathyroidism) is rare, but possible.
Dr. Philip Kern
Dr. Philip Kern
Thank
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