Is there a negative interaction between bactrim (sulfamethoxazole and trimethoprim) ds and coumadin?

Interaction checker. You can use a drug interaction checker whenever you have questions about drug-drug interactions or drug - food interactions. Here is one option (Drugs.Com): https://www.drugs.com/drug_interactions.php Your pharmacist is also an excellent source of information.
Yes. Bactrim (sulfamethoxazole and trimethoprim) ds increases effects of Coumadin by decreasing metabolism, by plasma protein binding competiton, and through hepatic enzyme cyp2c9/10 metabolism. Significant interaction possible.Monitor closely. Use alternatives if available.

Related Questions

Why is there an interaction between Coumadin and bactrim (sulfamethoxazole and trimethoprim)?

Increases free drug. Much of Coumadin is bound to protein. Many drugs, including bactrim, (sulfamethoxazole and trimethoprim) dislodge it from protein and increase the free (active) drug in the circulation. This usually results in a sharp spike in the inr and can lead to bleeding. If you must take batrim, you may need to skip a dose or two of coumadin. Discuss with your doctor. Read more...

I have a sinus infection and just started Bactrim (sulfamethoxazole and trimethoprim) DS yesterday. I've been reading all the negative reviews. Worried about side effects. Is Bactrim (sulfamethoxazole and trimethoprim) ok?

Usually no problem. It indeed can be alarming to read lists of drug side effects. But for Bactrim, (sulfamethoxazole and trimethoprim) most of them are rare and few are permanent or dangerous. The vast majority of people who take it have no probem at all. And your doctor wouldn't have prescribed it unless she believed it would be more helpful than harmful. But recheck with the doctor if you remain concerned. Read more...
Mostly it is fine. Bactrim (sulfamethoxazole and trimethoprim) is a great antibiotic except in some patients it can cause a serious skin rashes associated with Itching. You will likely do fine if there is no rash during the first few days. Good luck. Read more...

32 y/o female, symptoms of UTI including urgency, urethral discomfort, flank pain. Urine negative, no retention. Rx Bactrim (sulfamethoxazole and trimethoprim) DS. PMH pyelo x2. Ideas?

HC of pyelonephritis. When you are told that the urine test was - it just means it did not grow on the culture media that they chose to grow on. Try taking Ellura, a cranberry extract which prevents the bacteria from attaching to your bladder wall. It's not an antibiotic but it works quite well. Read more...

Are there any interactions between bactrim (sulfamethoxazole and trimethoprim) and olive leaf extract? Or can I take them simultaneously? Also, Bactrim (sulfamethoxazole and trimethoprim) & garlic extract/monoluarin?

Most important thing. you must know when taking Bactrim (sulfamethoxazole and trimethoprim) is that it can form crystals in your kidneys if you don't hydrate enough. So taking larges amount of filtered water to protect your kidneys is paramount. Olive leaf extract which is the heart of the mediterranean diet should not pose a problem, but it's always good to take your supplements separately from your medications in general. You can take UR supplements. Read more...

Bactrim (sulfamethoxazole and trimethoprim) have any negative effect?

Yes. There are many potential side effects and toxicities from bactrim (sulfamethoxazole and trimethoprim). Most common would be nausea, vomiting, diarrhea and various skin rashes. Bone marrow , liver and renal toxicity can also occur. That being said, most patients tolerate this drug combination with little or no difficulty. Read more...