Can a twisted ankle be the cause of swollen lymph nodes in the groin?

Doubtful. After obtaining a medical history, examination and any needed studies - your physician may be able to shed more life on your inguinal lymphadenopathy.
Monitoring Centers. Lymphatic system absorbs/carries things too big to go into the arteries/veins like bacteria eaten by white cells/digested food. Lymph nodes "taste" the lymph everywhere for bad stuff like bacteria/viruses/cancers, etc. When it detects a problem, it alerts the immune system and your body reacts. They enlarge in response to the inflammation they create when they react. They shrink when all is well.
Not usually. Groin nodes enlarge when the body is trying to clear an inflammation or infection of the limb they drain. An ankle sprain could causes unilaterally swelling (one side only). But one must rule out another cause first (infection particularly) before attributig it t an ankle injury.

Related Questions

What can cause swollen lymph nodes in groin/neck?

It depends. We need to know more . How long have you had these nodes and what is their size? Are they increasing in size? if they are bigger than 2 Cm and increasing in size in 1 to 2 months, you need to be examined by a physician. If the nodes are suspicious for Cancer, a biopsy is the best way to find out or exclude Cancer as the cause. Infections can also cause swelling of lymph nodes(Tender to touch) Read more...

What could cause swollen lymph nodes in groin and back pain?

Hard to say. There are several possible cause of such symptoms. The best approach is to see your doctor for a complete exam. They may wish to get a ct scan depending on the results of the findings on exam. Read more...

It is possible to have swollen lymph nodes in the neck because of sinusitis and other in the groin caused by small cut in the leg, at the same time?

Lymphadenopathy LAD. Or swollen lymph nodes are commonly due to infections and resolve shortly after the infection is over. For example, an upper respiratory infection such as sinusitis may cause lad in the neck & resolves w/ in a few weeks. Lad at a site distal to the source of infection (e.g. An infected toe leading to lad in the groin) must be examined by a doctor to rule out a possible serious underlying condition. Read more...
Possible, Possible, but , make sure they are back to normal in 2 weeks and not getting bigger. If so then need to. Get. Check. Up. Read more...