How long does it take for the Depo-Provera shot to get out of your system?

Depends. Depo Provera (medroxyprogesterone) is used for birth control. It can be administered im or sq. The half life of an im injection is 50-55 days, a bit longer for sq. This means the medication will remain in your system 250-275 days.(5x the 1/2 life).