Can I take msm powder (methyl-sulfonyl-methane) while on prozac (fluoxetine)?

Similar side effects. There are no known drug interactions between msm and prozac (fluoxetine). However, some of the same side effects with msm may be present with Prozac (fluoxetine) including diarrhea, bloating, insomnia, headache and nausea. Msm also contains sulfa, so if you are allergic to sulfa medications, it would be better not to take this supplement. Always consult with your physician.