? I'm not sure i understand the question; however, no absolute size cutoff establishes "end stage" lymphoma. Lymphomas are often seen that have very large lymph nodes. That might be an adverse prognostic factor (staging: x = bulky) but doesn't necessarily mean end stage. What is important are lymphoma type, prognostic factors, and response to treatment.
Not necessarily . Stage of lymphoma has to do with extent of involvement, not size of nodes. Stage i can be a huge lymph node in only 1 spot and stage 4 could have nothing but normal sized nodes but involvement of multiple areas or organs (liver, brain, blood, spinal fluid, etc).