My wife works in a large department store, standing 8 hours a day; her knees started hurting as most others?

New shoes. I'd recommend that your wife wears shoes at the store that are more comfortable and supportive. There are some dress shoes that accomplish that for women. Depending on her age, it would be worth an evaluation for osteoarthritis. The treatments can include tylenol, (acetaminophen) nsaids (like aleve), steroid injections, and use of a cain. Regardless, the knee pain is likely improved with physical therapy.

Related Questions

My wife works in a large department store, standing 8 hours a day, her knees started hurting as most others?

Yeah. No doubt of that. If she has arthritis, she may get a doctor's note to allow her to sit if her work permits or she may consider changing jobs if unable to tolerate. Read more...
Patellar pain. If it's both knees, then it's probably kneecap related pain (patellar pain), from prolonged standing. She should ice the knees for 20 minutes at a time, 3-4 times per day. Also, an over the counter anti-inflammatory medication would be helpful. Read more...