How slowly would one have to lose weight to avoid large amounts of loose skin?

Shoot for 1-2 lbs/wk. How slow you lose weight is not as important as how much weight you desire to lose in determining lose skin. A person who has well over a 100 lbs to lose will most likely have lose skin, no matter how slow they lose the weight. Healthy weight lose by dieting, should be no more than 1-2 pounds weekly. Under a physicians care this can be faster as long as it is monitored.