Can fluconazole interact badly with any of these meds:zolpidem er, propranolol, sprintec, lexapro, (escitalopram) melatonin?

Ok. No significant interactions between Fluconazole and any of the mentioned meds.
Yes they can. Fluconazole/lexapro can prolong qt internal and cause cardiac arrhythmias. Lexapro (escitalopram) can also increase Propranolol levels and effects., talk w/your doctor, .