Genetic disorder. It is a genetic disorder characterized by abnormal sodium channels, which affect a great deal of problems including the respiratory and digestive systems. It is most commonly diagnosed in infants failing to gain appropriate weight, and in children who have multiple chronic infections.
Genetic disease. CF is a mutation in the gene that codes for the sodium-chloride transporter in certain cells. There are various known (and unknown) mutations that lead to either a nonfunctioning or absent protein or a less effective protein. This leads to thick mucus in the airway and in the pancreas - and may lead to disfunction in other cell types (infection fighting cells, etc).