10 doctors weighed in:
Do you recomend Zetia (ezetimibe) for reducing cholesterol, or you prefer welchol?
10 doctors weighed in

Dr. Bennett Werner
Internal Medicine - Cardiology
3 doctors agree
In brief: Neither
While both drugs lower cholesterol (which is a surrogate end point for preventing heart disease), neither drug has been shown to actually prevent heart disease.
Statins (like crestor, lipitor, (atorvastatin) and zocor) have, by far, the best proven track record for secondary and primary prevention of heart disease. For people with side effects, very tiny doses are usually well tolerated and probably effective.

In brief: Neither
While both drugs lower cholesterol (which is a surrogate end point for preventing heart disease), neither drug has been shown to actually prevent heart disease.
Statins (like crestor, lipitor, (atorvastatin) and zocor) have, by far, the best proven track record for secondary and primary prevention of heart disease. For people with side effects, very tiny doses are usually well tolerated and probably effective.
Dr. Bennett Werner
Dr. Bennett Werner
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Dr. Vasudev Ananthram
Internal Medicine - Cardiology
2 doctors agree
In brief: Certain patients
Zetia (ezetimibe) added to a statin has a much greater cholesterol lowering benefit than welchol and may be appropriate in certain patients.

In brief: Certain patients
Zetia (ezetimibe) added to a statin has a much greater cholesterol lowering benefit than welchol and may be appropriate in certain patients.
Dr. Vasudev Ananthram
Dr. Vasudev Ananthram
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2 comments
Dr. Vincent Granowicz
both are good drugs for people unable to tolerate statins. welchol has fewer side effects.
Dr. Bennett Werner
Neither Zetia nor Welchol have outcome data. Only statins have been shown to lower major adverse cardiac events and death. Most people can tolerate small doses of statins for example 5 mg of Crestor is well tolerated by the majority of people with muscle aches. It can be taken daily or every other day with surprisingly good results
Dr. William Cromwell
Clinical Lipidology
1 doctor agrees
In brief: Both Have Merit
Both Zetia (ezetimibe) and welchol work to decrease cholesterol absorption from the gut.
The effect is an increase in LDL receptors that result in reducing circulating LDL particles. Welchol has the added effect of reducing blood hemoglobin a1c levels, the measure of glucose levels over a 3 month period, by 0.5 mg%. Rarely are these agents used 1st line. Rather, they are added to statins where appropriate.

In brief: Both Have Merit
Both Zetia (ezetimibe) and welchol work to decrease cholesterol absorption from the gut.
The effect is an increase in LDL receptors that result in reducing circulating LDL particles. Welchol has the added effect of reducing blood hemoglobin a1c levels, the measure of glucose levels over a 3 month period, by 0.5 mg%. Rarely are these agents used 1st line. Rather, they are added to statins where appropriate.
Dr. William Cromwell
Dr. William Cromwell
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Dr. Binyomin Nemon
Family Medicine
In brief: Depends
Depends what works for you (you are a unique individual).
Speak to your physician.

In brief: Depends
Depends what works for you (you are a unique individual).
Speak to your physician.
Dr. Binyomin Nemon
Dr. Binyomin Nemon
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