Can vaginal 'wetness' interfere with male orgasm with vaginal penetration?

Vaginal wetness. Vaginal wetness should not interfere with make orgasm an vaginal penetration. In fact it should make it easier. There are a wide variety of over the counter agents such as KY jelly that are intended for this exact purpose. You should have this evaluated by your gynecologsit to ensure that no other condtion is responsible.
Yes but rarely. If the female partner is so wet that there is not enough friction, then the male partner might have a problem getting enough stimulation to achieve an orgasm. This happens, but it is uncommon.