I am 44 years old. I have a strong family history of ovarian/breast cancer and braca2 of unknown significance. I getvery painful menstrual cramps. Could I have ovarian cancer?
The curse of the VUS. Personal and family history trumps genetic testing. If you have strong family history of breast/ovarian cancer, it could be that the vus is truly a deleterious mutation yet to be identified as such or have another gene involved besides brca. I would advise you see your gyn and a specialist with expertise in genetic testing/risk assessment. They will go over ways to reduce cancer risk for you.
Painful Menses are. Not a sign of ovarian ca but need regular exams, inculding mammogram. Depending on the chances of your variant, some consider a hysterectomy with ovarian removal. Low dose estrogen only hormone replacement would be much less estrogen than u are making, getting off too quick can have other problems, including cv disease and osteoporosis. If u consider ov removal, low dose hrt need 2b considered.
My bio mother had breast cancer at a young age, and my bio grandmother had ovarian cancer. Both passed from it. Prophylactic mastectomy an option?
Depends. If you are 18 years old, that is a very early age to be considering mastectomy surgery. It would be best to see your family doctor and get a referral to a genetic counselor for consideration of brca testing to see what your risks are. You may or may not have a higher risk of breast and/or ovarian cancers. Be checked first before considering the worst. Read more...
Possibly. Brca 1 and 2 are genetic mutations that can be passed through families, and those affected have a higher than average risk of developing those kinds of cancers. Would recommend appointment with a genetic counselor and consider getting that test done. If positive, then you and your doctor can make a plan for higher intensity monitoring or prophylactic surgery. Read more...