Uric acid. An over accumulation of uric acid can lead to gout. If the uric acid crystallizes, it starts a painful arthritic reaction. A gout attack is one of the most severe joint pains that you can experience. The most common site is the big toe. Gout can cause joint deformity. The good news is that gout is a very treatable disease with dietary changes and medications.
A Systemic. Disease that can manifest itself in the foot. The joint will be swollen, red, hot and very painful.