What helps calm an upser stomach?

Upset stomach. It would depend on the cause of your upset stomach. It may be due to viral gastroenteritis, food poisoning, medication side effects, lactose intolerance, ibs, h. Pylori gastritis or peptic ulcers. You could try zantac, (ranitidine) pepcid, maalox, or Prilosec otc. But if it's not going away, please see a doctor for evaluation.