9 doctors weighed in:

Is it true that you shouldn't take ibuprofen if you are on zoloft (sertraline)?

9 doctors weighed in
Dr. Andrew Oswari
Family Medicine
5 doctors agree

In brief: Technically

Technically there is an interaction between nsaids and zoloft.
Celebrex (celecoxib) is safe to take with it though.

In brief: Technically

Technically there is an interaction between nsaids and zoloft.
Celebrex (celecoxib) is safe to take with it though.
Dr. Andrew Oswari
Dr. Andrew Oswari
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Dr. Kevin Nasky
Psychiatry
3 doctors agree

In brief: Not necessarily.

In general, not a problem to take both.
I believe there is a moderate risk of gastrointenstinal bleeding when both ssris and nsaids are taken chronically (i.e. Every day), though i don't think there's any research showing significant risk of occasional NSAID use in patients taking ssris. It would be important to know what other GI bleeding risks you have, if any.

In brief: Not necessarily.

In general, not a problem to take both.
I believe there is a moderate risk of gastrointenstinal bleeding when both ssris and nsaids are taken chronically (i.e. Every day), though i don't think there's any research showing significant risk of occasional NSAID use in patients taking ssris. It would be important to know what other GI bleeding risks you have, if any.
Dr. Kevin Nasky
Dr. Kevin Nasky
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Dr. Peter Corrado
Family Medicine
2 doctors agree

In brief: Yes

Zoloft (sertraline) may increase the side effects of Ibuprofen leading to increased bleeding.
In addition, Ibuprofen may decrease the effectiveness of zoloft (sertraline). Not a good combination.

In brief: Yes

Zoloft (sertraline) may increase the side effects of Ibuprofen leading to increased bleeding.
In addition, Ibuprofen may decrease the effectiveness of zoloft (sertraline). Not a good combination.
Dr. Peter Corrado
Dr. Peter Corrado
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