Upper GI. Hsv also known as herpes has two types. Hsv 1 usually affects sensory nerves in the face and head. Hsv 2, the sensory nerves in the genital tract. Both viruses can infect any sensory nerve in the body so HSV 1 can be found on the hand pens/vagina. I do not know of any cases where HSV caused symptoms in the lower GI tract but it can cause out breaks in the mouth and throat.