No. There was a small study comparing safflower oil and conjugated linoleic acid (cla) in which a significant loss of abdominal fat in postmenopausal women with diabetes. you cannot say that safflower oil supplements will help trim your waste line based on this study as it was a very small study on select patients.
No. Our body makes hormones based on consumption of fatty acids. Safflower oil contains lots of polyunsaturated omega 6 fatty acids, which tend to increase inflammation, blood clotting, and cell proliferation, while those from omega 3 fatty acids decrease those effects. Sources of omega 6 are numerous in modern diets as in polyunsaturated vegetable oils as in safflower oil.