How does a genetic mutation cause sickle-cell disease?

Abnormal protein. One genetic mutation such as the one that is found in sickle cell causes abnormal hemoglobin beta chains to form which result in sickling of the hemoglobin since it can't go to its normal shape. The sickling of the hemoglobin and red blood cell gets caught in small vessels leading to all of the problems associated with sickle cell disease.

Related Questions

Hiya, what are the causes of sickle cell anemia? I know it is inherited but I need it explained in a way that can tell me the causes of gene mutation.

Gene mutations. are random. The sickle gene confers some resistance to malaria due to the abnormal configuration of hemoglobin. Sickle trait/sickle cell anemia is most prevalent in populations where malaria is or was endemic. It is likely that the mutation conferred some competitive advantage due to its antimalarial effects and was promulgated through natural selection. Read more...
2 doses of gene. SSA occurs when the baby gets a sickle gene from both parents.This gene causes the cell to deform (sickle) in some conditions in the body.These cells break down easier resulting in anemia.If they only get 1 sickle gene the good 2nd gene keeps it from deforming.The mutation was random and occurred 10's of thousands of years ago. Being a carrier of one gene makes you less likely to die from malaria. Read more...

Is sickle cell anemia purely a genetic disorder?

I Don't Think So. I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have. Read more...

What type of genetic disorder is sickle cell anemia or trait?

Hemoglobinopathy. Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms. Read more...

What's the rate of occurrence of sickle cell disease (gene frequency, and mutation rate)?

Sickle. What is the rate of occurrence for the disease sickle cell anemia or disease?" -- the occurrence rate is 25% if both parents are carriers, 50% if one parent has it and another parent is a carrier and 100% if both parents have it. Roughly 1, 000 infants are born, in the U.S., with it each year. Read more...

Which is the rate of occurrence of sickle cell disease (gene frequency, and mutation rate)?

Depends on geography. Given the single base change responsible for sickle cell trait in the beta globin gene, the frequency of new mutations is essentially zero. According to the cdc in the usa, 8-10% of african americans have sickle cell trait and 0.2% have sickle cell disease. Conversely, in western africa, the prevalence of sickle cell trait is 30-40%. Read more...

Is sickle cell disease genetic?

Yes. The recessive sickle gene is carried silently in a percentage of the population.When two carriers produce offspring their is 25% risk with each conception that an affected baby will be born. Read more...

Can genetic testing for sickle cell disease be done before birth of baby?

Genetic test Sickle. Yes the test is done on high risk women at the 17 week of gestation by doing amniocentesis with the permission of both patents. Read more...

Can you explain to me how mutation take place in sickle-cell anemia?

Important gene... Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease. Read more...