What to tell me about sickle cell anemia?

See below. Sickle cell anemia occurs when 2 abnormal hemoglobin genes are present and a person's body produces sickle cell hemoglobin exclusively. 1 sickle cell gene and a normal gene produce sickle trait, which has no symptoms. Other abnormal hemoglobin genes can combine with a sickle cell gene and produce other types of anemia. There are several other genetic hemoglobin abnormalities.

Related Questions

At my last check up, I forgot to tell the doctor about sickle cell anemia. Is that ok?

Should tell your doc. It is important to tell your doctor that you have sickle cel anemia as sickle cell anemia can be complicated with crisis episode ( pain crisis, acute chest syndrome, stroke etc) that requires complex management. So, call you roctor and tell him/her about it. Read more...
No! If you're saying you yourself have sickle cell anemia and you failed to tell a doctor caring for you about this diagnosis, it certainly is not ok! ssa can have a tremendous number of long-term issues that your doctor might not look for or manage appropriately if he or she is unaware of the diagnosis. I'm hoping you forgot because you had very few problems with your ssa when you were a child! Read more...

Please tell me the cause of sickle cell anemia?

Stiffened hemoglobin. There is a genetic change that causes an abnormal hemoglobin. This abnormal hemoglobin becomes stiff in certain circumstances, causing the red blood cell to sickle. This causes many symptoms, including anemia, pain, and many other symptoms. Read more...
Gene defect. Years ago a mutation in a gene (set of instructions) used to form hemoglobin appeared. A single gene of a pair conferred some resistance to malaria, a germ that invades red cells. With a normal gene paired with the defect, they were able to live normally. If 2 defective genes appear in a person, their red cells are stiff & breakdown quickly (anemia) & are unable to get easily through capillaries. Read more...

Can you please tell me how sickle cell disase and sickle cell anemia differ?

It depends. This often gets confusing because doctors don't always use terms the same way. Sickle cell anemia typically refers to the condition where a person inherits two s genes; by convention hematologists call this ss. This is also a type of sickle cell disease, but often hematologist include other diseases like sc disease (one s gene, one c gene) or s/beta thal under the umbrella of sickle cell disease. Read more...

Can you tell me how is sickle cell anemia passed down?

Genetic. Sickle cell disease is a genetic condition. You get one set of genes from each of your parents. If they both carry the gene, it is possible for them to pass it to their child. If both parents pass the affected gene, then the child will have sickle cell disease. If one parent passes it to the child, then the child will be a carrier but not be affected by sickle cell disease. . Read more...

Can you please tell me genetics of sickle cell anemia?

Inherited disease. Sickle cell disease is genetic and is present at birth. It is inherited when a child receives two sickle cell genes—one from each parent. This disease is more common in blacks (people of african heritage). Sickle cell trait occurs when one sickle cell gene (“s”) is inherited from one parent and one normal gene (“a”) from the other. Those with trait are "carriers" and are often asymptomatic. Read more...
Sickle cell disease. Occurs when both copies of their beta globin gene (one received from each parent) harbor a mutation in codon 6 that changes the encoded Amino Acid from glutamate to valine. Patients can't make normal hemoglobin consequently, and instead can only make hgbs. If you inherit one normal and one beta-s, you can make some normal (hgba) and some hgbs. The normal hgba limits sickling. This is sickle trait. Read more...

Can you please tell me why it'sthat only carriers of sickle cell anemia are immune to malaria?

Both carriers and . People with the disease are protected (not immune). People with trait historically were more likely to survive into adulthood to pass along the sickle cell gene. People with ss hemglobin, until recently, were not likely to survive into adulthood to have children. Read more...
Sickle Cell /Malaria. In a person who has sickle-cell trait – the red blood cells are destroyed prematurely before the Plamodium can reproduce. According to one study “Sickle cell trait provides 60% protection against overall mortality. Most of this protection occurs between 2-16 months of life, before the onset of clinical immunity in areas with intense transmission of malaria.” . Read more...

Could you tell me what gene is affected by sickle cell anemia?

The beta globin gene. Hemoglobin is a complicated molecule in red blood cells that carries oxygen from the lungs to the rest of the body. It contains 4 protein chains, 2 Alpha chains and 2 beta chains. Sickle cell disease is caused by specific mutation in the beta globin gene. We each have two beta globin genes. If one has the s mutation you have sickle trait; if both have the s mutation you have sickle cell anemia. Read more...
Beta globin . The beta globin gene is on chromosome 11. The gene mutation is a Adenosine to thymine base substitution in the gene that changes the normal glutamic acid in position 6 of beta globin protein with valine. Read more...

Hiya, what are the causes of sickle cell anemia? I know it is inherited but I need it explained in a way that can tell me the causes of gene mutation.

Gene mutations. are random. The sickle gene confers some resistance to malaria due to the abnormal configuration of hemoglobin. Sickle trait/sickle cell anemia is most prevalent in populations where malaria is or was endemic. It is likely that the mutation conferred some competitive advantage due to its antimalarial effects and was promulgated through natural selection. Read more...
2 doses of gene. SSA occurs when the baby gets a sickle gene from both parents.This gene causes the cell to deform (sickle) in some conditions in the body.These cells break down easier resulting in anemia.If they only get 1 sickle gene the good 2nd gene keeps it from deforming.The mutation was random and occurred 10's of thousands of years ago. Being a carrier of one gene makes you less likely to die from malaria. Read more...