While driving my husbands hands go numb. He also experiences numbness when applying pressure on his left leg. What could this be from and what to do.?

Various etiologies. There are a number of different possible causes for this, from vitamin deficiency to nerve compression to pressure on his spinal cord. There are a few other things that could lead tho this, have him go get this worked up by his physician so that the cause is appropriately addressed.
2 conditions. These are unrelated complaints. The hand numbness may be carpal tunnel syndrome vs pinched cervical nerves. Numbness with the left leg is more likely a pinched nerve in the lumbar spine. Further evaluation with a physician is warranted if symptoms persist and/or are debilitating.

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