Diet and exercise. There are no otc supplements that will help you lose weight, except in your wallet. Why put something in your body that you don't know what it is or what it will do to you. Diet and exercise are the only things that work long term. Don't get your medical information from friends, tv or the internet.
None. Do not waste your money on the online hucksters who want to sell you supplements that are "legal". Do not buy stuff with ephedrine (ephedrine sulfate). Just eat less.
The best way to lose. Weight is to reduce your calorie intake and increase your activity. Supplements are usually unnecessary when appropriate life style choices are made. Save your money and go for a walk (away from the refrigerator) instead.
Just be sensible. The real key to weight loss is to just watch the size of your portions at meals, eat healthy, and exercise regularly. There's no radical diet or exercise plan or pill that will magically give you meaningful and sustained weight loss. The ol' fashioned way is still be best way to lose weight for the long term. Two pounds per week is a prudent rate of loss.
Colon cleanse. If you are not experiencing constipation colon cleanse does not apply. If you have frequent constipation see your doctor. If you are looking for weight loss you should consider changing your eating habits (see "Nuval" on the internet), and get in some more exercise if you have time.