Pt 60 years, well controlled dm and htn, now suddenly developing ankle edema progressing chf? , discontinue pioglitazone+metformin+glimepride?

Swelling. Do not stop any medication on your own. Need to discuss with doctor that is treating your CHF and dm.
Ankle edema. I am not sure of your question, but it sounds like you need to be seen by a physicain.
See a physician. Ankle edema could be a sign of many conditions, not just chf. I would not recommend stopping treatments until the patient is thoroughly evaluated by a md. There are more specific tests for CHF on history (shortness of breath), exam (neck veins, heart sounds, lung sounds, abdomen) and tests for heart, liver and kidney disease (chest x-ray, ekg, blood and urine proteins, gfr, and others).