6 doctors weighed in:

My baby's father is over 40, will he be more prone to birth defects?

6 doctors weighed in
Dr. Jeff Livingston
Obstetrics & Gynecology
3 doctors agree

In brief: Slightly higher risk

There is a link between paternal age and some birth defects but the overall risk is low.
The current scientific explanation is that dna changes occur more frequently in sperm as men ages. The risk is low and increases with the age of the man.

In brief: Slightly higher risk

There is a link between paternal age and some birth defects but the overall risk is low.
The current scientific explanation is that dna changes occur more frequently in sperm as men ages. The risk is low and increases with the age of the man.
Dr. Jeff Livingston
Dr. Jeff Livingston
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1 comment
Dr. J. Lawrence Dohan
Down syndrome more common in offspring of older parents, especially fathers. Can be diagnosed early in pregnancy and parents can decide to act or not.
Dr. Jeff Livingston
Obstetrics & Gynecology

In brief: Not really

Paternal age of 40 is not link led to genetic abnormalities like maternal age.
Maternal age increases risk above 35. For men the risk increases around age 70.

In brief: Not really

Paternal age of 40 is not link led to genetic abnormalities like maternal age.
Maternal age increases risk above 35. For men the risk increases around age 70.
Dr. Jeff Livingston
Dr. Jeff Livingston
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Dr. Johanna Fricke
Pediatrics - Developmental & Behavioral

In brief: ACMG suggestions:

The american college of medical genetics says there is no standard definition of " advanced paternal age" & risks increase linearly as men age, rather than begin at age 40.
They recommend prenatal counseling for couples & fetal ultrasound at 18 weeks, but add that fus will not necessarily show issues of interest. Some studies show increased risk of autistic disorders & single-gene mutations.

In brief: ACMG suggestions:

The american college of medical genetics says there is no standard definition of " advanced paternal age" & risks increase linearly as men age, rather than begin at age 40.
They recommend prenatal counseling for couples & fetal ultrasound at 18 weeks, but add that fus will not necessarily show issues of interest. Some studies show increased risk of autistic disorders & single-gene mutations.
Dr. Johanna Fricke
Dr. Johanna Fricke
Thank
Dr. James Ferguson
Pediatrics

In brief: Rarely

The biological clock women face is not as harsh on males.
The difference comes with how the sperm is generated vs the egg.New sperm come from stem cells & males can produce healthy sperm well into there 60's, while women are born with all the eggs they will ever have.The egg must survive the years of moms toxic exposures & remain good.Any bad sperm don't swim as well as the good ones.

In brief: Rarely

The biological clock women face is not as harsh on males.
The difference comes with how the sperm is generated vs the egg.New sperm come from stem cells & males can produce healthy sperm well into there 60's, while women are born with all the eggs they will ever have.The egg must survive the years of moms toxic exposures & remain good.Any bad sperm don't swim as well as the good ones.
Dr. James Ferguson
Dr. James Ferguson
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