Red Pimple like bump on leg, no white head. Day 2 itchy & flaky, scratch it. Day 3 nickle size now, red, little pain, itchy, 2 dots appear in middle like spider bit or no hair in follicles. No fever or nausea. Don't recall a bit. What might it be?

Bite. In view of the itching, I think it's an insect bite. For relief of itching, apply a cortisone type ointment. If spreading redness occurs, secondary infection may be present and oral antibiotics may be needed. At the very least apply an antibacterial ointment. See your MD as needed.