What could happen if someone with asthma and acute bronchitis breathe in air with PM 2.5 particle index 322 (hazardous level) due to smoke from wildfires? Will the use of rescue inhaler cause more toxic air getting inside the lungs?

The basics. All the air we breathe has extraneous particles of some sort unless it comes through a well designed filter. Increasing particulate in the air has the potential to trigger the protective mechanisms of the lung which is what triggers in asthma. Rescue inhalers allow an asthmatic to release some bronchospasm & function like unaffected people. Not using an inhaler when needed is more risky.