Hi, I went to see doctor for spider bite that has gotten progressively worse since inception on Sunday evening/Monday morning. I have received antibiotics, but it seems to be getting even worse. Should I pop it?

No. If it has formed a blister, it's not recommended that you pop it. Apply warm soaks and then keep the area clean and dry. You can apply an antibiotic ointment like bacitracin. If progressive swelling or worsening redness develop, have the wound reexamined.