Is there any difference between Piroxicam, Indomethacin, and Diclofenac, for pain relief? Is one of them a more potent analgesic?

NSAIDs. These are all nonsteroidal anti-inflammatory medications and I rate them equally potent and urge caution in their usage. They are much more potent than the popular Advil and Aleve and,as such, are more apt to cause serious side effects-especially piroxicam and indomethicin. Very short term use is advisable and only with your MD's prescription and supervision.