What if blood was on tissue when I wiped my butt?

?hemorrhoid. Most common cause of blood on tissue paper is hemorrhoidal bleed. However, one can have hemorrhoids in addition to other more serious causes of rectal bleed. So one should discuss this with one's doctor. You might also want to type in "colon" or "hemorrhoid" on the "ask your doctor" box, scroll down to "see more results" and read great additional doctor's answers/comments this subject.