4 doctors weighed in:

Is it safe to skip one day of Fluoxetine? I take 20mg each Morning but experience diarrhea every night right after dinner (regardless of the time I eat dinner or food that I eat). Can skipping a day avoid the diarrhea that day?

4 doctors weighed in
Dr. Charles Turck
Pharmacology

In brief: Diarrhea

Diarrhea occurs in 8-18%, but it typically lasts 1-2 weeks after starting the medication or changing the dose.
Don’t skip on your own; you may delay the time it takes to get to where your dose is effective, which is usually 4-6 weeks. It’s worth letting your doctor know about these symptoms early. See Comment

In brief: Diarrhea

Diarrhea occurs in 8-18%, but it typically lasts 1-2 weeks after starting the medication or changing the dose.
Don’t skip on your own; you may delay the time it takes to get to where your dose is effective, which is usually 4-6 weeks. It’s worth letting your doctor know about these symptoms early. See Comment
Dr. Charles Turck
Dr. Charles Turck
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1 comment
Dr. Charles Turck
You may be told to take something like Immodium but if your symptoms keep up and become intolerable, your doctor may decide to switch your medication. Depending on how severe, they may also indicate other conditions too (irritable bowel syndrome).
Dr. John Goldman
Internal Medicine - Rheumatology

In brief: Probably not

Fluoxetine phas a long half life and diarrhea can be a side effect you need to consider asking your physician to evaluate you and see if there’s another cause for the diarrhea and if not you may need a therapy change.
Since it has a long half-life stopping it May not have much of an effect.

In brief: Probably not

Fluoxetine phas a long half life and diarrhea can be a side effect you need to consider asking your physician to evaluate you and see if there’s another cause for the diarrhea and if not you may need a therapy change.
Since it has a long half-life stopping it May not have much of an effect.
Dr. John Goldman
Dr. John Goldman
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Dr. Jeffrey Hoffman
Family Medicine

In brief: Try it

Fluoxetine has a half life of 3 days.
.. you could take it every other day or every third day and see if it helps

In brief: Try it

Fluoxetine has a half life of 3 days.
.. you could take it every other day or every third day and see if it helps
Dr. Jeffrey Hoffman
Dr. Jeffrey Hoffman
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Dr. Paul Pyles
Addiction Medicine

In brief: Yes and No

Fluoxetine has a relatively long half-life.
Missing a dose will not harm you. However, it may not reduce your likelihood of avoiding diarrhea. Your best option is to discuss your symptom or side effect with your prescribing provider. You may need to switch to a different class of antidepressant because medications in the SSRI class are known to have GI side effects. Best wishes.

In brief: Yes and No

Fluoxetine has a relatively long half-life.
Missing a dose will not harm you. However, it may not reduce your likelihood of avoiding diarrhea. Your best option is to discuss your symptom or side effect with your prescribing provider. You may need to switch to a different class of antidepressant because medications in the SSRI class are known to have GI side effects. Best wishes.
Dr. Paul Pyles
Dr. Paul Pyles
Thank
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