Every 2ish yrs for the last 10, I have an allergic reaction to something, but the cause is never determined nor clear. Angioedema ruled out last time. Could this be something other than an allergy? Symptoms: tight throat, extreme hives, itchy tongue.

Urticaria/angioedema. is what you described, not sure what did you mean when you mentioned that angioedema was ruled out ! those recurrent acute attacks warrant keeping injectable epinephrine handy as well as antihistamines to use in case you need them again. You need to be evaluated by an allergist/immunonlogist, or a dermatologist, check aaaai.org or acaai.org for an allergist in your area, best wishes.