6 doctors weighed in:

Can a child have sickle cell trait if neither parent has it but the paternal grandfather does?

6 doctors weighed in
Dr. Jovita Anyanwu
Internal Medicine
3 doctors agree

In brief: No

Both parents may need a repeat hemoglobin electrophoresis as it is likely that one of the biological parents have at least a sickle cell trait which is usually asymptomatic

In brief: No

Both parents may need a repeat hemoglobin electrophoresis as it is likely that one of the biological parents have at least a sickle cell trait which is usually asymptomatic
Dr. Jovita Anyanwu
Dr. Jovita Anyanwu
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Dr. James Ferguson
Pediatrics
2 doctors agree

In brief: No

If neither the mother or father of that child carries the sickle gene, they can not pass it on to their own child to give them trait.
In such a case, it stopped at the paternal grandparent.

In brief: No

If neither the mother or father of that child carries the sickle gene, they can not pass it on to their own child to give them trait.
In such a case, it stopped at the paternal grandparent.
Dr. James Ferguson
Dr. James Ferguson
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Dr. Thomas Anker
Family Medicine

In brief: Mendelian?

If sickle cell is inherited in a classic mendelian pattern and a child carries the trait, then it was most likely passed down from a parent.
If the parent does not have it then one of two possibilities: 1. de novo mutation 2. sickle cell trait is more complicated than simple mendelian inheritance pattern and if so, likely because more than a single mutation can cause the trait.

In brief: Mendelian?

If sickle cell is inherited in a classic mendelian pattern and a child carries the trait, then it was most likely passed down from a parent.
If the parent does not have it then one of two possibilities: 1. de novo mutation 2. sickle cell trait is more complicated than simple mendelian inheritance pattern and if so, likely because more than a single mutation can cause the trait.
Dr. Thomas Anker
Dr. Thomas Anker
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