I'm not as sexually active as I used to, and I'm on the depo shot. If I'm off it, will weight drop or stay? Will I experience spotting? Return of period?

Yes to all. If you decide to come off of the depo shot, you will slowly see irregular spotting and return of your period, but it will take a little time for things to go back to normal. Usually (but not always), patients will lose a little weight as well but it depends on the individual, what your diet is like, level of physical activity, etc. Hope this helps.