Bipolar type 2, anxiety. My psych just increased Effexor to 337.5mg. I am am average height/weight male. Isn't that insanely high?

No. While most people respond to doses of 75-225 mg per day, many people with more severe or refractory depression may require doses up to 350 mg per day. If you are having side effects, which may be related to the dose, you should report them to your psychiatrist and/or discuss with your pharmacist. If you are not, it may take 4-6 weeks to see the full effects. Continue all your meds. Good luck.