Our fertility clinic has informed us that our egg donor has a mutation of the DUOX2 gene. My husband does not. Is this mutation clinically significant? What follow-up information do I need to ask for? Should I request another donor?
Yes. it is clinically significant. 1 mutation is milder than 2. but this is a situation where 1 mutation can cause a problem. so either find a new donor or meet with a genetic counselor to decide whether to use her. it does not mean she cannot be used you just need to be counseled.