What should I do to better the symptoms of coming off of depo provera? I have been going through hell.

Progesterone. supplementation may help. Get natural progesterone cream at a reputable vitamin/supplement stores that contains 25mg of natural progesterone per dose. Used cyclically (see instructions), it can help you get through the withdrawal phase of the depo provera. You can also use ibuprofen for cramping, and exercise daily to help with mood swings and fatigue. Cut back on caffeine and alcohol,too.