Does this affect my Skyla at all? Natural Change Blend SP-7D (red clover black cohosh pomegranate red raspberry wild yam fenugreek seed butternut fennel)

All good. the hormone contained in a Skyla IUD (Levonorgestrel) generally Works within the uterus. because very little of the hormone ever makes it into the bloodstream, it is not affected by medications you take or things you eat like with birth control pills. This is why IUD's are a fantastic method of birth control.
Probably not. Although it sounds as though it probably would not affect it, nutritional supplements are not tested or overseen by any regulatory agency, so it is impossible to know for sure what you're getting. You should discuss any potential interactions with your OB/GYN. Hope that helps.